I want to...

Automate Throughput	Decrease Labor Prep Time
Reduce Input gDNA	Stop Using Manual Slab Gels
Analzye Larger Fragments	Eliminate Clean Up Step
Increase Throughput	Reduce Time To Results
Eliminate Labeled Primers

I want to Stop Using Manual Slab Gels

Trying to use agarose or acrylamide slab gels for mutation detection is both challenging and time consuming. Standard agarose gels inherently lack sensitivity and resolution capabilities sufficient to easily visualize the cleaved fragments of typical pooling levels. Meanwhile, acrylamide slab gels are tedious to prepare and require significant amounts of hands-on time and labor to load and manipulate.

The AdvanCE™ FS Nucleic Acids Analyzer is a better alternative to slab gel. Not only does it provide high detection sensitivity and superior resolution unmatched by agarose and nondenaturing acrylamide slab gels, it does not require fluorescent labeled primers nor the use of toxic chemical required of denaturing acrylamide gels.

With the AdvanCE™ FS Nucleic Acids Analyzer sample handling is automated and hands-on time is drastically reduced as compared to slab gel methods. Several key opinion leaders from major Universities and Corporations have adapted the AdvanCE™ FS Nucleic Acids Analyzer platform to replace the traditional denaturing acrylamide method. (Make sure to click on our Technical Resources tab to access their posters and presentations.) They have chosen to use the AdvanCE™ FS Nucleic Acids Analyzer for the following reasons:

Reason	AdvanCE™ FS Advantage
Eliminate use of fluorescent labeled primers	Save on reagent costs
Amplify larger fragments, (i.e. >1,500 bp)	Able to screen bigger regions, saves time
Reduce input genomic DNA	Save on precious materials, more reactions
Fast electrophoresis times	More runs per day with less labor
High resolution gels	Able to accurately determine cleaved fragment size

The AdvanCE™ FS Nucleic Acids Analyzer can be used to eliminate slab gels by

1. Increasing detection sensitivity and resolution.
2. Requiring minimal daily maintenance and operating at a low cost of ownership.
3. Being designed to be used by multiple users.