Literature

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  • Brochures
    View Title
    REQUEST Oligo PRO™ Automated Purity Analyzer
    REQUEST pKa PRO™ Measurement System
    REQUEST Protein PRO™ Protein Analysis System
    REQUEST AdvanCE™ FS96 Parallel Fluorescent CE System
    REQUEST DNA PROfiler™ Genetic Identification System
  • Applicaton Notes
    • Parallel Capillary Electrophoresis
      (pKa PRO™, Oligo PRO™, Protein PRO™, cePRO™)
      View Title
      pKa/pI Measurements
      REQUEST Aqueous pKa Measurement Using the pKa PRO™
      log P Measurements
      REQUEST High Throughput Estimation of Octanol-Water Partition Coefficients (log Pow Values) by Multiplexed-Microemulsion Electrokinetic Chromatography with the MCE 2000(tm) System
      Chiral Analysis
      REQUEST High Throughput Chiral Separations using the cePRO 9600™ System
      General Applications - Parallel Capillary Electrophoresis
      REQUEST Performance Characteristics of the cePRO 9600™ System Part I: Migration Time and Peak Area Precision
      REQUEST Multiplexed Micellar Electrokinetic Chromatography (MMEKC) Separations with the cePRO 9600™ System: Protein Tryptic Digest Analysis
    • Fragment Analyzer™ Automated System
      View Title
      High-Throughput Screening
      REQUEST High-Throughput Mutation Screening on a TILLING Platform using the Fragment Analyzer™ Automated system
      REQUEST Simple, High Throughput and Cost Effective Analysis of SSR (Microsatellite, STR) Fragments Using the Fragment Analyzer™ System
  • Presentations
    • Parallel Capillary Electrophoresis
      (pKa PRO™, Oligo PRO™, Protein PRO™, cePRO™)
      View Title
      pKa/pI Measurements
      REQUEST Measurement of pKa Values, Isoelectric Point and Stability of Small Molecules and Peptides by Parallel Capillary Electrophoresis with UV Absorbance Detection.  AAPS National Meeting. 2007.
      log P Measurements
      REQUEST High Throughput Screening of Compound Lipophilicity (log P) Values Using Multiplexed, Absorbance-Based Capillary Electrophoresis.  log P 2004 Conference. 2004.
      Chiral Separation
      REQUEST High Throughput Enantiospecific Separations Using Multiplexed Capillary Electrophoresis with Absorbance Detection. 56th Pittsburgh Conference on Analytical Chemistry and Applied Spectroscopy. 2005.
      pdf       PDF High Throughput Enantiospecific Separations Using Multiplexed Capillary Electrophoresis with Absorbance Detection.  Chirality 2004 Meeting. 2004.
      DNA/RNA Oligonucleotide Purity Analysis
      REQUEST High Throughput Characterization of Oligonucleotide and RNAi Duplex Purity by Parallel Capillary Electrophoresis.  RNAi, MicroRNAs & Oligos-2009-Boston Summit. 2009.
      REQUEST Rapid Characterization of Synthetic Oligonucleotide and RNA Duplex Purity by Parallel Capillary Electrophoresis with UV Absorbance Detection. AAPS National Meeting. 2007.
      pdf       PDF Comparisons between Multiplexed, Absorbance-based Capillary Electrophoresis, Capillary Electrophoresis, and Ion Exchange Chromatography for Analysis of n-1 Oligonucleotide Impurities. TIDES Meeting. 2005.
      Antibody/Protein Analysis
      REQUEST Protein PRO™ Technology Overview. June 2009.
      dsDNA Fragment Analysis
      REQUEST High Throughput dsDNA Fragment Detection and Analysis by Parallel Capillary Electrophoresis with Fluorescent Detection. Jan 2010 PAG XVIII
    • DNA PROfiler™ Genetic Identification System
      View Title
      Profiling for Microorganism Identification, ASM 2008
      REQUEST DNA Profiling for Rapid Mycobacterium Identification with the Use Genbank Information as Reference Library. ASM 2010
      REQUEST Aspergillus Identification with DNA PROfiling. ASM 2010
      REQUEST Pathogenic Candida Species Identification with DNA Profiling. ASM 2009
      REQUEST DNA Profiling for Characterization of Salmonella spp. ASM 2009
      REQUEST The Use of the DNA PROfiler™ for the Identification of Mycobacterium species. ASM 2009
      REQUEST DNA PROfiling for Detection and Characterization of Salmonella in Peanut Butter. IAFP 2010
  • Publications
    • pKa/pI Measurements
      View Title
      LINK Evaluation of Multiplexed CE with UV Detection for Rapid pKa Estimation of Active Pharmaceutical Ingredients. Chromatographia, (2008): 219-225. http://www.springerlink.com
      pdf       PDF Measurement of Dissociation Constants (pKa Values) of Organic Compounds by Multiplexed Capillary Electrophoresis Using Aqueous and Cosolvent Buffers. J. Pharm. Sci. 97 (2008): 2581-2606.
      LINK Physicochemical Profiling by Capillary Electrophoresis (Review). Curr. Pharm. Anal. 1 (2005): 41-56. http://www.bentham.org/cpa/sample/cpa1-1.htm#52008
      pdf       PDF Rapid pKa Estimation using Vacuum-Assisted Multiplexed Capillary Electrophoresis (VAMCE) with Ultraviolet Detection. J. Pharm. Sci. 94 (2005): 576-589.
      LINK Determination of Acid Dissociation Constants by Capillary Electrophoresis (Review). J. Chromatogr. A 1037 (2004): 445-454. http://www.sciencedirect.com
      LINK Semi-Empirical Relationships between Effective Mobility, Charge, and Molecular Weight of Pharmaceuticals by Pressure-Assisted Capillary Electrophoresis. Applications in Drug Discovery. Electrophoresis 23 (2002): 2833-2841. http://www3.interscience.wiley.com/journal/98515345/abstract
    • log P Measurements
      View Title
      LINK Physicochemical Profiling by Capillary Electrophoresis (Review). Curr. Pharm. Anal. 1 (2005): 41-56. http://www.bentham.org/cpa/sample/cpa1-1.htm#5
      pdf       PDF Validation and Long-Term Assessment of an Approach for the High Throughput Determination of Lipophilicity (log P) Values Using Multiplexed, Absorbance-Based Capillary Electrophoresis. J. Pharm. Sci. 93 (2004): 916-931.
      pdf       PDF The Application of Multiplexed Microemulsion Electrokinetic Chromatography for the Rapid Determination of log P Values for Neutral and Basic Compounds. LCGC North Am. 21 (2003): 1078-1088.
      LINK Separation Methods for Estimating Octanol-Water Partition Coefficients (Review). J. Chromatogr. A 797 (2003): 3-19. http://www.sciencedirect.com
    • Chiral Analysis
      View Title
      pdf       PDF High-Throughput Chiral Separations Using the cePRO 9600™ Multiplexed Capillary Electrophoresis System. LCGC 22 (September 2004), S28-S29. (Advertising Supplement).
      LINK Combinatorial Enantiomeric Separation of Diverse Compounds Using Capillary Array Electrophoresis. Electrophoresis 23 (2002): 2996-3005. http://www3.interscience.wiley.com/journal/98515364/abstract  
    • Process Monitoring
      View Title
      LINK Parallel Capillary Electrophoresis for the Quantitative Screening of Fermentation Broths Containing Natural Products. Metab. Eng. 7 (2005): 53-58. http://www.sciencedirect.com
      REQUEST Combinatorial Screening of Homogeneous Catalysis and Reaction Optimization Based on Multiplexed Capillary Electrophoresis. J. Comb. Chem. 2 (2000): 450-452. http://pubs.acs.org/doi/abs/10.1021/cc000043b
    • Capillary Electrophoresis
      View Title
      Instrumentation – Parallel Capillary Electrophoresis
      LINK An Absorption Detection Approach for Multiplexed Capillary Electrophoresis Using a Linear Photodiode Array. Anal. Chem. 71 (1999): 4989-4996. http://pubs.acs.org/doi/abs/10.1021/ac9900634
      Reviews – Capillary Electrophoresis
      pdf       PDF High-Throughput Multiplexed Capillary Electrophoresis in Drug Discovery. Drug Discovery Today 9 (2004): 1072-1080.
      pdf       PDF High-Throughput Characterization and Quality Control of Small-Molecule Combinatorial Libraries. Curr. Opin. Chem. Biol. 8 (2004): 418-423.
      REQUEST Techniques for High-Throughput Characterization of Peptides, Oligonucleotides, and Catalysis Efficiency. Curr. Opin. Chem. Biol. 8 (2004): 327-333.
      REQUEST Overview of the Status and Applications of Capillary Electrophoresis to the Analysis of Small Molecules. J. Chromatogr. A 1023 (2004): 1-14.
  • Manuals

    Instruction Manuals for single capillary gels

    View Title
    Protigel
    pdf       PDF Protigel™ – A sc Manual
    pdf       PDF Protigel™ – P sc Manual
    Oligel
    pdf       PDF Oligel™ sc Manual
    pdf       PDF Native Oligel™ sc Manual